Longer-acting clotting factor concentrates for hemophilia
نویسندگان
چکیده
منابع مشابه
Changing paradigm of prophylaxis with longer acting factor concentrates.
Beginning in the 1960s the care of persons with haemophilia began to improve dramatically through a series of transformative improvements in care: development of lyophilized factor concentrates, home care programmes, prophylaxis and (due to the tragedy of HIV/hepatitis) the development of virally safer plasma-derived and recombinant factor concentrates. Prophylaxis, if commenced early and given...
متن کاملRecent evolution of clotting factor concentrates for hemophilia A and B. Transfusion Practices Committee.
TRANSFUSION1993—Vol. 33, No, 5FACTOR CONCENTRATES 1992433 12. Finlayson JS, Tankersley DL, Anti-HCV screening and plasmafractionation: the ease against (letter). Lancct 1990;335:1274-5.13. Pneumocystis carina pneumonia among persons with hemophiliaA . MMWR Morb Mortal Wkly Rep 1982;31:365-7.14. Krciss JK, Kitchen LW, Princc HE, Kasper CK, Essex M . Antibody to h...
متن کاملActivated clotting factors in factor IX concentrates.
The precise quantitation of activated factors in human factor IX concentrates has been accomplished with the use of recently developed, specific assays for factors IXa, Xa, and thrombin. The assay for factor IXa, which measures the initial rate of 3H-factor-X activation, was shown to be specific for factor IXa in the concentrates. Activated factor IX concentrates contained 1.0-2.3 microgram/ml ...
متن کاملThe History of Clotting Factor Concentrates Pharmacokinetics
Clotting factor concentrates (CFCs) underwent tremendous modifications during the last forty years. Plasma-derived concentrates made the replacement therapy feasible not only in the hospital but also at patients' home by on-demand or prophylactic regimen. Virucidal methods, implemented soon after hepatitis and AIDS outbreak, and purification by Mabs made the plasma-derived concentrates safer an...
متن کاملFactor concentrates for treatment of hemophilia: which one to choose?
U NTIL THE ADVENT of components that could more specifically replace specific missing clotting factors, patients with hemophilia were treated with whole blood and then plasma. Such patients had a shortened lifespan and were crippled with severe anthropathy; many died of hemonrhage. With the discovery in 1960 that factor VIII:C was concentrated in cryoprecipitate, more specific replacement for p...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2015
ISSN: 1538-7933
DOI: 10.1111/jth.12912